HRID1639437

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID156232

(R)-3-Phenoxy-mandelonitrile

C14H11NO2

$结构：CC1(C)[C@H](C(=O)O)[C@@H]1/C=C\C(=O)OCC(F)F$

HCID86740318

未命名化合物

PRODUCTS

生成物

$结构：CC1(C)[C@H](C(=O)O[C@@H](C#N)c2cccc(Oc3ccccc3)c2)[C@@H]1/C=C\C(=O)OCC(F)F$

HCID86740317

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

Using the procedure of Step F of Example 9, (1R,cis) 2,2-dimethyl-3-[(Z) 3-oxo-3-(2,2-difluoroethoxy)-1-propenyl]-cyclopropane-carboxylic acid and (R)α-cyano-3-phenoxy-benzyl alcohol were reacted to obtain (R)α-cyano-3-phenoxy-benzyl (1R,cis) 2,2-dimethyl-3-[(Z) 3-oxo-3-(2,2-difluoroethoxy)-1-propenyl]-cyclopropane-carboxylate with a specific rotation of [α]D20 =+117.5°±3° (c=0.6% in chloroform).

WORKUP

后处理

customwere reacted