反应详情

900 mg of (S)α-cyano-3-phenoxy-benzyl (IR,cis) 2,2-dimethyl-3-[(Z) 3-chloro-3-oxo-1-propenyl]-cyclopropane carboxylate were dissolved in 3 ml of methylene chloride and 1 ml of 1-trifluoromethyl-1-methyl propanol was added thereto. The mixture was stirred for 16 hours at room temperature under inert atmosphere and away from humidity. After 3 days at room temperature, the reaction mixture was washed with a saturated aqueous solution of sodium bicarbonate, then with water, dried and evaporated to dryness. The residue was chromatographed over silica gel and eluted with a 8-2 mixture of hexane-ethyl ether to obtain 570 mg of (S)α-cyano-3-phenoxy-benzyl (IR,cis) 2,2-dimethyl-3-[(Z) 3-oxo-3-(1-trifluoromethyl-1-methyl-propyloxy) -1-propenyl]-cyclopropane-carboxylate.

1. waitAfter 3 days at room temperature
2. washthe reaction mixture was washed with a saturated aqueous solution of sodium bicarbonate
3. dry with materialwith water, dried
4. customevaporated to dryness
5. customThe residue was chromatographed over silica gel
6. washeluted with a 8-2 mixture of hexane-ethyl ether