HCID 66722830, compound → HCID 66722929, compound

HRID 1639540Notes

Reaction equation

HRID 1639540 reaction equation
C(OC1C=CC(N2CCOCC2)=CC=1C(OCC1C=CC=CC=1)=O)C1C=CC=CC=1.C([O:38][C:39]1[CH:47]=[CH:46][C:45]([N:48]2[CH2:53][CH2:52][O:51][CH2:50][CH2:49]2)=[CH:44][C:40]=1[C:41]([NH2:43])=[O:42])C1C=CC=CC=1>>[OH:38][C:39]1[CH:47]=[CH:46][C:45]([N:48]2[CH2:49][CH2:50][O:51][CH2:52][CH2:53]2)=[CH:44][C:40]=1[C:41]([NH2:43])=[O:42]

Participants

3

Reactant 2

HCID 66722830HCID 66722830, compoundHCID 66722916HCID 66722916, compound

Product 1

HCID 66722929HCID 66722929, compoundYield 83%

Procedure

In a manner identical to Example 140, 121 mg (0.30 mmol) of benzyl 2-benzyloxy-5-(morpholin-4-yl)benzoate is converted to 2-benzyloxy-5-(morpholin-4-yl)benzamide which on hydrogenolysis gives 56 mg (0.25 mmol, 83% yield) of 2-hydroxy-5-(morpholin-4-yl)benzamide.

Sources & evidence

ORD record
ord-00d9a67fa5264cce998e0fbc16631b65
Source dataset
uspto-grants-2012_02
Patent number
US08110570B2

Reaction notes

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