2-Morpholinoethylamine → HCID 86622285, compound

Participants

Reaction Steps

In a 10 cm3 tube, 200 mg of methyl(6-hydroxy-1,3-benzothiazol-2-yl)carbamate are suspended in 6 cm3 of 1-methyl-pyrrolidin-2-one, and 580 mg of 2-morpholin-4-ylethylamine are added. After closing, the tube is placed in the microwave oven at a temperature in the region of 150° C. for about 25 minutes. After concentrating to dryness under reduced pressure, the residue obtained is purified by flash chromatography on a column of silica [eluent: dichloromethane/methanol (95/5 by volume)]. 270 mg of 1-(6-hydroxy-1,3-benzothiazol-2-yl)-3-(2-morpholin-4-ylethyl)urea are thus obtained in the form of a resin, the characteristics of which are as follows:

Provenance & Evidence