Cyclopropanecarboxylic acid → HCID 178522512, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 468 mg of N-[(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methylmethanaminium hexafluorophosphate in 5 cm3 of dimethylformamide are added 159 mg of diisopropylethylamine and 106 mg of cyclopropanecarboxylic acid. After stirring the reaction medium for one hour at a temperature in the region of 20° C., 220 mg of 2-amino-1H-benzimidazol-5-yl 2,6-dichlorobenzenesulfonate are obtained. The mixture is stirred overnight at a temperature in the region of 20° C. The reaction medium is diluted with 50 cm3 of water and the insoluble material is filtered off, washed with three times 5 cm3 of water, filtered off by suction and dried under a stream of air. The solid obtained is solidified in 10 cm3 of a mixture of diethyl ether and acetonitrile (7/3 by volume) and then filtered off by suction, washed with three times 2 cm3 of diethyl ether and dried under reduced pressure over phosphorus pentoxide. 98 mg of 2-[(cyclopropylcarbonyl)amino]-1H-benzimidazol-5-yl 2,6-dichlorobenzenesulfonate are obtained in the form of a white powder, the characteristics of which are as follows:

Provenance & Evidence