Potassium Hydroxide → HCID 66720841, compound

Participants

Reaction Conditions

Reaction Steps

956 mg of methyl 2-imino-6-[(methoxycarbonyl)oxy]-1,3-benzothiazole-3(2H)-carboxylate are placed in 38 cm3 of aqueous 5N potassium hydroxide solution in a three-necked flask. The solution is stirred at a temperature in the region of 20° C. for 5 hours. The reaction medium is placed in a bath at 0° C., and acetic acid is then added dropwise to pH 5-6. The precipitate is filtered off by suction and then washed with twice 5 cm3 of water. The solid is taken up in 10 cm3 of water, stirred for two hours and then filtered off by suction, washed with twice 2 cm3 of water and dried under a stream of air. 270 mg of methyl 6-hydroxy-2-imino-1,3-benzothiazole-3(2H)-carboxylate are obtained in the form of a white powder, the characteristics of which are as follows:

Provenance & Evidence