2,1,3-Benzoxadiazole-5-carbonyl chloride → HCID 25192137, compound

HRID 1639677Notes

Reaction equation

HRID 1639677 reaction equation
[CH:1]12[CH2:7][CH:4]([O:5][CH2:6]1)[CH2:3][NH:2]2.[N:8]1[O:9][N:10]=[C:11]2[CH:16]=[C:15]([C:17](Cl)=[O:18])[CH:14]=[CH:13][C:12]=12>>[N:8]1[O:9][N:10]=[C:11]2[CH:16]=[C:15]([C:17]([N:2]3[CH2:3][CH:4]4[CH2:7][CH:1]3[CH2:6][O:5]4)=[O:18])[CH:14]=[CH:13][C:12]=12

Participants

3

Reactant 2

HCID 27354532,1,3-Benzoxadiazole-5-carbonyl chlorideHCID 36145512-Oxa-5-azabicyclo(2.2.1)heptane

Product 1

HCID 25192137HCID 25192137, compound

Procedure

The title compound was prepared from 2-aza-5-oxabicyclo[2.2.1]heptane and [2,1,3]-benzoxadiazole-5-carbonylchloride as described for Example 7: mp=102-104° C., LC-MS, MH+=246; 1H NMR (300 MHz, CDCl3) δ 7.98-7.90 (m, 2H), 7.58 (dd, J=1.2 and 9.3 Hz, 1H), 5.08 and 4.78 (s, total 1H), 4.66 and 4.47 (s, total 1H), 4.05 (m, 1H), 3.89 (m, 1H), 3.73-3.63 (m, 1H), 3.52 (s, 1H), 2.06-1.95 ppm (m, 2H).

Sources & evidence

ORD record
ord-7bf3b32e00514ed89e06cd3d86569fda
Source dataset
uspto-grants-2012_02
Patent number
US08110584B2

Reaction notes

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