反应详情

温度

100 °C

A mixture of ethyl 4-(hydroxymethyl)-2-methylpyrazolo[1,5-a]pyridine-3-carboxylate (41.0 g, 0.180 mol) and 40% aqueous sulfuric acid solution (350 mL) was stirred at 100° C. for 2 hr. The reaction mixture was basified with 10% aqueous sodium hydroxide solution, and extracted with dichloromethane. The extract was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure to give the title compound (28.0 g, yield 99%).

1. extractionextracted with dichloromethane
2. dry with materialThe extract was dried over anhydrous sodium sulfate
3. customthe solvent was evaporated under reduced pressure