Hydrogen chloride-ethyl acetate → 1-[(1R,2R)-2-(2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine dihydrochloride

Participants

Reaction Steps

To a solution of tert-butyl {[(1R,2R)-2-(2-methyl-2H-indazol-4-yl)cyclopropyl]methyl}carbamate (2.68 g, 8.89 mmol) in ethyl acetate (50 mL) was added 4 M hydrochloric acid/ethyl acetate (50 mL) solution, and the mixture was stirred at room temperature for 2 hr. The solvent was concentrated under reduced pressure, and the obtained crystals were washed with ethyl acetate to give the title compound (2.38 g, yield 98%).

Provenance & Evidence