Hydrochloride methanol → 1-[(1S,2S)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine dihydrochloride

HRID 1639785Notes

Reaction equation

HRID 1639785 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[CH:5][N:6]([CH3:11])[N:7]=2)[C:3]=1[C@H:12]1[CH2:14][C@@H:13]1[CH2:15][NH:16]C(=O)OC(C)(C)C.[ClH:24].CO>CO>[ClH:24].[ClH:24].[F:1][C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[CH:5][N:6]([CH3:11])[N:7]=2)[C:3]=1[C@H:12]1[CH2:14][C@@H:13]1[CH2:15][NH2:16]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 59334635tert-butyl {[(1S,2S)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methyl}carbamate

Product 1

HCID 667206561-[(1S,2S)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine dihydrochlorideYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of tert-butyl {[(1S,2S)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methyl}carbamate (315 mg, 0.986 mmol) in methanol (1 mL) was added hydrochloric acid-methanol reagent (manufactured by TCI, 3 mL) solution, and the mixture was stirred at room temperature for 14 hr. The solvent was concentrated under reduced pressure and the obtained crystals were washed with ethyl acetate to give the title compound (297 mg, yield 100%).

Workup

  1. concentrationThe solvent was concentrated under reduced pressure
  2. washthe obtained crystals were washed with ethyl acetate

Sources & evidence

ORD record
ord-ae91e40f9d7844b48fa747a6facb284d
Source dataset
uspto-grants-2012_02
Patent number
US08110585B2

Reaction notes

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