Hydrochloride methanol → 1-[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine dihydrochloride

HRID 1639786Notes

Reaction equation

HRID 1639786 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[CH:5][N:6]([CH3:11])[N:7]=2)[C:3]=1[C@@H:12]1[CH2:14][C@H:13]1[CH2:15][NH:16]C(=O)OC(C)(C)C.[ClH:24].CO>CO>[ClH:24].[ClH:24].[F:1][C:2]1[CH:10]=[CH:9][C:8]2[C:4](=[CH:5][N:6]([CH3:11])[N:7]=2)[C:3]=1[C@@H:12]1[CH2:14][C@H:13]1[CH2:15][NH2:16]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 59334581tert-butyl {[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methyl)carbamate

Product 1

HCID 667206571-[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methanamine dihydrochlorideYield 79%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of tert-butyl {[(1R,2R)-2-(5-fluoro-2-methyl-2H-indazol-4-yl)cyclopropyl]methyl}carbamate (343 mg, 1.07 mmol) in methanol (1 mL) was added hydrochloric acid-methanol reagent (manufactured by TCI, 3 mL) solution, and the mixture was stirred at room temperature for 14 hr. The solvent was concentrated under reduced pressure and the obtained crystals were washed with ethyl acetate to give the title compound (246 mg, yield 79%).

Workup

  1. concentrationThe solvent was concentrated under reduced pressure
  2. washthe obtained crystals were washed with ethyl acetate

Sources & evidence

ORD record
ord-128c43b9f008436c96c6c9b17e422daa
Source dataset
uspto-grants-2012_02
Patent number
US08110585B2

Reaction notes

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