反应详情

A mixture of a crudely purified product (6.00 g, purity 50%) of methyl 4-fluoro-2-methyl-3-nitrobenzoate and wet palladium carbon (10 wt %, 300 mg, 2.81 mmol) in methanol (100 mL) was stirred under hydrogen atmosphere for 4 hr. The catalyst was filtered off through celite, the filtrate was concentrated under reduced pressure, and the residue was purified by flash silica gel column chromatography (ethyl acetate/hexane=1/20→1/10) to give the title compound (2.13 g, yield 42%).

1. filtrationThe catalyst was filtered off through celite
2. concentrationthe filtrate was concentrated under reduced pressure
3. customthe residue was purified by flash silica gel column chromatography (ethyl acetate/hexane=1/20→1/10)