Sodium sulfate decahydrate → HCID 59334574, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of lithium aluminum hydride (695 mg, 18.3 mmol) in tetrahydrofuran (30 mL) was added a solution of ethyl 2-(7-fluoro-2-methyl-2H-indazol-4-yl)cyclopropanecarboxylate (1.20 g, 4.58 mmol) obtained in Reference Example 81 in tetrahydrofuran (15 mL) under nitrogen atmosphere at 0° C., and the mixture was stirred at 0° C. for 15 min. Sodium sulfate decahydrate (7.0 g) was added under ice-cooling, and the mixture was filtered through celite. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography (ethyl acetate/hexane=15/85→100/0) to give the title compound (961 mg, yield 95%).

Provenance & Evidence