Hydrochloride methanol → 1-[(1S,2S)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methanamine dihydrochloride

HRID 1639816Notes

Reaction equation

HRID 1639816 reaction equation
[CH3:1][C:2]1[CH:22]=[C:5]2[C:6]([C@H:10]3[CH2:12][C@@H:11]3[CH2:13][NH:14]C(=O)OC(C)(C)C)=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1.[ClH:23].CO>CO>[ClH:23].[ClH:23].[CH3:1][C:2]1[CH:22]=[C:5]2[C:6]([C@H:10]3[CH2:12][C@@H:11]3[CH2:13][NH2:14])=[CH:7][CH:8]=[CH:9][N:4]2[N:3]=1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 59334527tert-butyl {[(1S,2S)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methyl}carbamate

Product 1

HCID 667206211-[(1S,2S)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methanamine dihydrochlorideYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of tert-butyl {[(1S,2S)-2-(2-methylpyrazolo[1,5-a]pyridin-4-yl)cyclopropyl]methyl}carbamate (1.84 g, 6.11 mmol) in methanol (6 mL) was added hydrochloric acid-methanol reagent (manufactured by TCI, 18 mL) solution, and the mixture was stirred at room temperature for 15 hr. The solvent was concentrated under reduced pressure to give the title compound (1.69 g, yield 100%).

Workup

  1. concentrationThe solvent was concentrated under reduced pressure

Sources & evidence

ORD record
ord-b735fdedf4014133bb17eb86c8dfba16
Source dataset
uspto-grants-2012_02
Patent number
US08110585B2

Reaction notes

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