反应详情

6-Bromopyridin-2-amine (25.0 g, 144 mmol) and 1-chloroacetone (20.0 mL, 251 mmol) were dissolved in ethanol (300 mL) and the mixture was heated under reflux for 3 days. The precipitated solid was collected by filtration and dissolved in dichloromethane. The solution was washed with saturated aqueous sodium hydrogen carbonate solution, and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (25.0 g, yield 75%).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 days
3. filtrationThe precipitated solid was collected by filtration
4. dissolutiondissolved in dichloromethane
5. washThe solution was washed with saturated aqueous sodium hydrogen carbonate solution
6. dry with materialdried over anhydrous sodium sulfate
7. customthe solvent was evaporated under reduced pressure