Methanol → Methyl 2-chloro-3-nitrobenzoate

Participants

Reaction Steps

A mixture of 2-chloro-3-nitrobenzoic acid (24.8 g, 123 mmol) and sulfuric acid (3.00 mL, 38.2 mmol) in methanol (400 mL) was stirred at. 80° C. for 12 hr. The solvent was evaporated under reduced pressure, and the residue was diluted with ethyl acetate. This mixture was washed with 10% aqueous sodium hydroxide solution, water and saturated brine and dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (26.5 g, yield 99%).

Provenance & Evidence