Sodium sulfate decahydrate → HCID 59334545, compound

Participants

Reaction Steps

To a suspension of lithium aluminum hydride (141 mg, 3.70 mmol) in tetrahydrofuran (10 mL) was added 2-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-5-yl)cyclopropanecarbaldehyde oxime (200 mg, 0.925 mmol) obtained in Reference Example 112 at room temperature, and the mixture was stirred at room temperature for 2 hr, and at 60° C. for 2 hr. Sodium sulfate decahydrate was added under ice-cooling, and the mixture was filtered through celite. The filtrate was concentrated under reduced pressure to give 1-[2-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-5-yl)cyclopropyl]methanamine as a crudely purified product.

Provenance & Evidence