HRID1639897

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID64354

Adamantanine

C11H17NO2

结构：CCOC(=O)c1ccc(-c2c(OC)cccc2OC)c(-c2ccc(Cl)c(OC3CCN(C)C3)c2)n1

HCID66720745

未命名化合物

PRODUCTS

生成物

结构：COc1cccc(OC)c1-c1ccc(C(=O)NC2(C(=O)O)C3CC4CC(C3)CC2C4)nc1-c1ccc(Cl)c(OCCN(C)C)c1

HCID66720978

未命名化合物

收率 50.5%

PROCEDURE

实验过程

According to the saponification/peptide coupling steps described in examples 1.7 and 1.8 respectively, starting from 250 mg (0.5 mmol) of ethyl 6-{4-chloro-3-[(1-methylpyrrolidin-3-yl)oxy]phenyl}-5-(2,6-dimethoxyphenyl)pyridine-2-carboxylate and 100 mg (0.51 mmol) of 2-aminoadamantane-2-carboxylic acid, we obtain 160 mg of 2-({[6-{4-chloro-3-[2-(dimethylamino)ethoxy]phenyl}-5-(2,6-dimethoxyphenyl)pyridin-2-yl]carbonyl}amino)adamantane-2-carboxylic acid in the form of white powder.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a27cbce2a4d4436cbcdc5796db2744a1
来源数据集: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08110579B2
来源说明: uspto-grants-2012_02

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14](OCC)=[O:15])[CH:11]=[CH:10][C:9]=2[C:19]2[C:24]([O:25][CH3:26])=[CH:23][CH:22]=[CH:21][C:20]=2[O:27][CH3:28])=[CH:4][C:3]=1[O:29][CH:30]1C[CH2:33][N:32]([CH3:35])[CH2:31]1.[NH2:36][C:37]1([C:47]([OH:49])=[O:48])[CH:44]2[CH2:45][CH:40]3[CH2:41][CH:42]([CH2:46][CH:38]1[CH2:39]3)[CH2:43]2>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([C:14]([NH:36][C:37]3([C:47]([OH:49])=[O:48])[CH:44]4[CH2:43][CH:42]5[CH2:41][CH:40]([CH2:39][CH:38]3[CH2:46]5)[CH2:45]4)=[O:15])[CH:11]=[CH:10][C:9]=2[C:19]2[C:20]([O:27][CH3:28])=[CH:21][CH:22]=[CH:23][C:24]=2[O:25][CH3:26])=[CH:4][C:3]=1[O:29][CH2:30][CH2:31][N:32]([CH3:35])[CH3:33]