2-Methylphenyl boronic acid → HCID 66720830, compound

HRID 1639914Notes

Reaction equation

HRID 1639914 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:16]2[C:17](OS(C(F)(F)F)(=O)=O)=[N:18][CH:19]=[C:20]([CH:25]=2)[C:21]([O:23][CH3:24])=[O:22])[CH:12]=[CH:13][C:14]=1[Cl:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1B(O)O>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:16]2[C:17]([C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][C:35]=3[CH3:34])=[N:18][CH:19]=[C:20]([CH:25]=2)[C:21]([O:23][CH3:24])=[O:22])[CH:12]=[CH:13][C:14]=1[Cl:15])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27332672-Methylphenyl boronic acidHCID 86637362HCID 86637362, compound

Product 1

HCID 66720830HCID 66720830, compoundYield 95%

Procedure

According to the method described in example 4.5, starting from 1.5 g (2.99 mmol) of methyl 5-[3-(benzyloxy)-4-chlorophenyl]-6-{[(trifluoromethyl)sulphonyl]oxy}nicotinate and of 508 mg (3.74 mmol) of 2-methylphenyl boronic acid, we obtain 1.26 g of methyl 5-[3-(benzyloxy)-4-chlorophenyl]-6-(2-methylphenyl)nicotinate in the form of oil.

Sources & evidence

ORD record
ord-35043e0ca4914d6bb5716b368201d01e
Source dataset
uspto-grants-2012_02
Patent number
US08110579B2

Reaction notes

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