Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Pyridine, 2,3,5-trichloro- | HCID 27666 | — |
| Reactant | HCID 66722410 | HCID 66722410 | — |
| Product | HCID 57970982 | HCID 57970982 | — |
Reaction Steps
A mixture of (5S)-2-(2-chlorophenyl)-2,7-diazaspiro[4.5]decan-1-one hydrochloride (18.2 mg, 0.0000604 mol), 2,3,5-trichloropyridine (16 mg, 0.000091 mol) and triethylamine (0.025 mL, 0.00018 mol) in N,N-dimethylformamide (0.4 mL, 0.005 mol) was irradiated with microwaves to heat the mixture to 180° C. for 20 min. The crude product was purified by prep-HPLC to afford the desired product. LC-MS: 410.1/412.1/414.0 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08110581B2 |
|---|
| Source dataset | uspto-grants-2012_02 |
|---|
| ORD ID | ord-6bc8f666911047048eb09cf5c2fd5d33 |
|---|
| Source note | uspto-grants-2012_02 |
|---|
