Acetonitrile → HCID 13737642, compound

Participants

Reaction Steps

15.0 mL of acetic anhydride (16.3 g, 160 mmol) was added dropwise to 62 mL of acetonitrile suspension of 6.2 g (50 mmol) of 2,6-dihydroxytoluene and 27.6 g (200 mmol) of potassium carbonate, which was stirred on an ice-water bath, over 3 minutes. The stirring was stopped 27 minutes later and the reaction mixture was allowed to stand at room temperature overnight and then filtered. The filtrate was stirred and settled in a separatory funnel as 100 mL of toluene and 50 mL of water was added. The aqueous layer was discarded, and the organic layer was washed with 25 mL of water twice, and the solvent was evaporated to obtain 10.3 g of title compound.

Provenance & Evidence