Aluminium lithium hydride → HCID 59229496, compound

Participants

Reaction Steps

A solution of 1-(3,5-bis-trifluoromethylphenyl)-2,2,2-trifluoro-1-(3-methyl-4-nitrophenyl)ethyl methanesulfonate (0.5 g) in tetrahydrofuran (5 ml) was slowly added dropwise to a solution of lithium aluminium hydride (0.04 g) in tetrahydrofuran (10 ml) in an ice bath. After stirring for 30 minutes, the reaction solution was diluted with ethyl ether, and then stirred for 30 minutes by slowly adding a saturated salt solution (1 ml). After the insoluble matter was separated by filtration, the solution was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and the residue was purified by silica gel column chromatography to obtain 1-(3,5-bis-trifluoromethylphenyl)-2,2,2-trifluoro-1-(3-methyl-4-nitrophenyl)ethane (0.11 g).

Provenance & Evidence