3-Nitro-5-(trifluoromethyl)benzoic acid → (3-Nitro-5-(trifluoromethyl)phenyl)methanol

Participants

Reaction Steps

To a solution of 3-nitro-5-(trifluoromethyl)benzoic acid (52.2 g, 0.222 mol) in THF (370 mL) at 0° C. was added BH3 (1M in THF, 444 mL) slowly. The reaction mixture was allowed to stir and warm to rt. After 30 min, the reaction was quenched by the addition of sat. aq. NaHCO3 at 0° C. and extracted with Et2O. The organic solutions were combined, washed with brine, dried over MGSO4, filtered and concentrated. The crude material (45.8 g, 93%) was used in the next step without purification.

Provenance & Evidence