HCID 58902321, compound → HCID 58902426, compound

Participants

Reaction Steps

A solution of tert-butyl (3-tert-butyl-5-cyanophenyl)carbamate (4.29 g, 0.0133 mol) in 4M HCl in dioxane (18 mL) was allowed to stir at rt for 2 h. The reaction mixture was concentrated to give 3-amino-5-tert-butylbenzonitrile (4.33 g, 93%) which was used without further purification. 1H NMR (300 MHz, CD3OD) δ: 7.99 (m, 1H), 7.72 (m, 1H), 7.56 (m, 1H), and 1.37(s, 9H). LCMS ES+ 175.1, ES− 173.1.

Provenance & Evidence