反应详情

To a solution of methyl 7-methoxy-1,2,3,4-tetrahydronaphthalene-2-carboxylate (4.03 g, 18.3 mmol), in MeOH (180 mL), was added 1N NaOH solution (73.2 mL, 73.3 mmol). The reaction was allowed to stir for 3 h and then the solvents were evaporated until approximately 50 mL of water remained. The solution was washed with Et2O and then the aqueous phase was acidified to pH 1 by the addition of 1N HCl solution. A precipitate formed and was filtered, washed with water and hexane, and dried under vacuum to give 7-methoxy-1,2,3,4tetrahydronaphthalene-2-carboxylic acid as a white solid (3.43 g, 91%).

1. customthe solvents were evaporated until approximately 50 mL of water
2. washThe solution was washed with Et2O
3. additionthe aqueous phase was acidified to pH 1 by the addition of 1N HCl solution
4. customA precipitate formed
5. filtrationwas filtered
6. washwashed with water and hexane
7. customdried under vacuum