Potassium Carbonate → HCID 58902343, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of N-(3-tert-butylphenyl)-7-({2-[(chloroacetyl)amino]pyridin-4-yl}oxy)-2-naphthamide (65.0 mg, 0.133 mmol) and potassium carbonate (36.8 mg, 0.266 mmol) in DMF (2 mL) was added 1-methylpiperazine (0.177 mL, 0.160 mmol). The reaction mixture was allowed to stir at 60° C. for 2 h. and then concentrated. EtOAc and water were added and the organic and aqueous solutions were separated. The organic solution was washed with brine, dried over MgSO4, filtered and concentrated. The residue was purified by column chromatography to give N-(3-tert-butylphenyl)-7-[(2-{[(4-methylpiperazin-1-yl)acetyl]-amino}pyridin-4-yl)oxy]-2-naphthamide I-264 ( ) (33 mg, 37%).

Provenance & Evidence