Chloride → HCID 86613296, compound

Participants

Reaction Steps

To a solution of 7-[(2-aminopyridin-4-yl)oxy]-N-(3-tert-butylphenyl)-1,2,3,4-tetrahydronaphthalene-2-carboxamide (1.50 g, 3.64 mmol) in THF (36 mL) at 0°, was added TEA (1.02 mL, 7.29 mmol) and then 2-chloropropanyoyl chloride (0.39 mL, 4.01 mmol) dropwise. The reaction was allowed to warm to rt and stir for 18 h. Water was added and the mixture was extracted with EtOAc (2×). The organic solutions were combined, washed with water, dried over Na2SO4 and concentrated. The residue was purified by column chromatography to give N-(3tert-butylphenyl)-7-({2-[(2-pyrrolidin-1-ylpropanyl)amino]pyridin-4yl}oxy)-1,2,3,4-tetrahydronaphthalene-2-carboxamide I-275 as a pale yellow solid (1.37 g, 74.9%).

Provenance & Evidence