Hydrochloric Acid → 6-(2'-Oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl-amino)pyrimidine-4-carboxylic acid-hydrochloride

Participants

Reaction Steps

5.0 mL (5.0 mmol) of a 1M aqueous lithium hydroxide solution were added to 1.80 g (4.48 mmol) ethyl 6-(2′-oxo-1,1′,2′,3-tetrahydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-5-ylamino)pyrimidine-4-carboxylate in 5.0 mL ethanol and the mixture was stirred overnight at RT. The reaction mixture was acidified with 1.3 mL of a 4M aqueous HCl solution and the precipitate formed was suction filtered and dried.

Provenance & Evidence