Formaldehyde → Methylene-(2-methyl-2-thiophen-3-yl-propyl)-amine

HRID 1640244Notes

Reaction equation

HRID 1640244 reaction equation
[CH3:1][C:2]([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)([CH3:5])[CH2:3][NH2:4].[CH2:11]=O>>[CH2:11]=[N:4][CH2:3][C:2]([CH3:5])([C:6]1[CH:10]=[CH:9][S:8][CH:7]=1)[CH3:1]

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 667224312-Methyl-2-(thien-3-yl)propylamine

Product 1

HCID 58117475Methylene-(2-methyl-2-thiophen-3-yl-propyl)-amine

Procedure

5.8 g (37 mmol) 2-methyl-2-thiophene-3-yl-propylamine and 3.6 mL (44 mmol) formaldehyde were stirred overnight together with 2.0 g molecular sieve (4 Å powder) at RT. The reaction mixture was filtered and the filtrate was concentrated to dryness by rotary evaporation.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated to dryness by rotary evaporation

Sources & evidence

ORD record
ord-521be5441c7d46b685e90d1ab04d17fb
Source dataset
uspto-grants-2012_02
Patent number
US08110575B2

Reaction notes

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