Sodium cyanoborohydride → 2-ethyl-6-fluoro-2,3-dihydro-1H-indole

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Reaction Steps

2.7 g (40 mmol) sodium cyanoborohydride were added to 1.6 g (10 mmol) 2-ethyl-6-fluoro-1H-indole in 20 mL conc. acetic acid and the mixture was stirred for 1 h at RT. The reaction mixture was evaporated down. The residue was mixed with 20 mL of a 4N HCl solution and stirred for 1 h at RT. Then 45 mL of a 4N sodium hydroxide solution was slowly added while cooling with ice and the mixture was extracted with ethyl acetate. The organic phase was dried on sodium sulphate and evaporated down.

Provenance & Evidence