Sodium Hydroxide → (6-Chloro-pyrimidin-4-yl)-(2-ethyl-6-fluoro-2,3-dihydro-indol-1-yl)-methanone

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.5 g (10 mmol) 2-ethyl-6-fluoro-2,3-dihydro-1H-indol in 25 mL dichloromethane was added at 0° C. to 1.8 g (10 mmol) 6-chloro-pyrimidine-4-carboxylic acid chloride in 25 mL dichloromethane and then 10 mL (10 mmol) of a 1M sodium hydroxide solution were added dropwise. The reaction mixture was stirred for 30 min at 0° C. and then for 1 h at RT. The organic phase was separated off and evaporated down. The residue was purified on silica gel.

Provenance & Evidence