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0 °C

A mixture of 0.76 g (4.7 mmol) 2-propyl-2,3-dihydro-1H-indole in 15 mL dichloromethane was added to 0.88 g (5.0 mmol) 6-chloro-pyrimidine-4-carboxylic acid chloride in 15 mL dichloromethane at 0° C. and then 4.7 mL (4.7 mmol) of a 1M sodium hydroxide solution were added dropwise. The reaction mixture was stirred for 30 min at 0° C. and then for 1 h at RT. The organic phase was separated off and evaporated down. The residue was purified on silica gel.

1. waitfor 1 h at RT
2. customThe organic phase was separated off
3. customevaporated down
4. customThe residue was purified on silica gel