HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (2-Chloro-pyridin-4-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloroisonicotinic acid | HCID 236985 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | 4,5-Difluoroindoline hydrochloride | HCID 44754918 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (2-Chloro-pyridin-4-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone | HCID 58117528 | — |
Reaction Steps
0.50 g (3.2 mmol) 2-chloroisonicotinic acid, 0.63 mg (3.3 mmol) 4,5-difluoroindoline-hydrochloride, 0.91 mL (6.5 mmol) TEA and 1.1 g (3.4 mmol) TBTU in 10 mL DMF were stirred overnight at RT. Then the reaction mixture was poured onto 200 mL of 15% potassium carbonate solution, the precipitate formed was suction filtered, washed with water and dried.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08110575B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-502a81c38aff4c36a91c8178357b894f |
| Source note | uspto-grants-2012_02 |