Dimethylformamide → N-(dicyclopropylmethyl)-N-methyl-6-(2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo-[2,3-b]pyridin]-5-ylamino)pyrimidine-4-carboxamide

Participants

Reaction Steps

1.2 equivalents (12 μmol) of the amine derivative, 3.4 equivalents DIPEA (34 μmol) and 1.20 equivalents (12 μmol) TBTU were added to 4.1 mg (10 μmol) 6-(2′-oxo-1,1′,2′,3-tetrahydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-5-ylamino)pyrimidine-4-carboxylic acid hydrochloride in 0.32 mL DMF and the mixture was shaken overnight at RT. The reaction mixture was evaporated down at 60° C. in a vacuum centrifuge. The following compounds were able to be synthesised analogously to this working method:

Provenance & Evidence