Diisopropylethylamine → 5-(6-(5,6,7,8-tetrahydro-4H-thiazolo[5,4-d]azepine-6-carbonyl)pyrimidin-4-ylamino)-1,3-di-hydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one

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Reaction Steps

86 mg (0.21 mmol) 6-(2′-oxo-1,1′,2′,3-tetrahydrospiro[indene-2,3′-pyrrolo[2,3-b]pyridin]-5-ylamino)pyrimidine-4-carboxylic acid hydrochloride, 37 mg (0.24 mmol) 5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine, 0.13 mL (0.72 mmol) DIPEA and 77 mg (0.24 mmol) TBTU in 1.0 mL DMF were stirred overnight at RT. The purification was carried out by preparative HPLC-MS. The product-containing fractions were combined and lyophilised.

Provenance & Evidence