Diisopropylethylamine → HCID 59508151, compound

Participants

Reaction Steps

DIEA (0.220 mL, 1.66 mmol) and 3-(3,4-Dichloro-benzoylamino)-6,6-dimethyl-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester (221 mg, 0.51 mmol) were added to a solution of 4-Fluoro-1-methyl-piperidine-4-carbonyl chloride (0.51 mmol) in CH2Cl2 (10 mL). The reaction was stirred at RT for 4 h. The mixture was quenched with H2O (30 mL), extracted with CHCl3 (2×30 mL). The organic layers were dried over MgSO4 and concentrated to give the title compound as brown color oil which was used without further purification. ESI (MNa+): 564.10.

Provenance & Evidence