HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethynylimidazo[1,2-b]pyridazine → N-(4-((4-(2-Hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethynylimidazo[1,2-b]pyridazine | HCID 46838760 | — |
| Reactant | N-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide | HCID 66736595 | — |
| Product | N-(4-((4-(2-Hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamide | HCID 24826879 | — |
Reaction Steps
The title compound was synthesized from 3-ethynylimidazo[1,2-b]pyridazine and N-(4-((4-(2-hydroxyethyl)piperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-iodo-4-methylbenzamide in a manner similar to that described for Example 14, The product was obtained as a solid: 563 m/z (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08114874B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-8fd32f8a86e44c53a7ec90273af8bbbc |
| Source note | uspto-grants-2012_02 |