tert-Butyl acetate → (RS)-3-hydroxy-3-(6-methoxy-[1,5]naphthyridin-4-yl)-propionic acid tert-butyl ester

Participants

Reaction Steps

The aldol reaction between 6-methoxy-[1,5]naphthyridine-4-carbaldehyde (1.9 g, 10 mmol, WO 2006/032466) and tert-butyl acetate (1.2 g, 10.5 mmol) was carried out as described in the literature (J. Org. Chem. (1990), 55, 4744-4750). The title compound was isolated after chromatography on SiO2 (Hex/EA 1:1) as a beige solid (2.33 g, 77% yield).

Provenance & Evidence