Triphenylphosphine → HCID 66737532, compound

Participants

Reaction Steps

A solution of 6-methoxy-quinolin-4-ol (0.54 g, 3 mmol) and (E)-4-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-but-2-en-1-ol (prepared according to J. Am. Chem. Soc. (2001), 123, 9525; 0.53 g, 3 mmol) in THF was treated with PPh3 (977 mg, 1.2 eq.) and dropwise with DIAD (0.77 mL, 1.2 eq.). The mixture was stirred at rt for 3 days, concentrated in vacuo and purified by FC (EA) to give the product as a yellowish oil (0.73 g, 72% yield).

Provenance & Evidence