6-amino-3,4-dihydro-2H-1,4-benzothiazin-3-one → HCID 66737820, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl-dimethyl-((S)-1-oxiranylmethoxy)-silane (13.0 g, 69 mmol) in acetonitrile (220 mL) was added LiClO4 (22 g, 207 mmol). 6-amino-4H-benzo[1,4]thiazin-3-one (11.4 g, 64 mmol) was added and the mixture was stirred at 50° C. for 6 h. The solvent was removed in vacuo and the residue was chromatographed (DCM/MeOH/NH4OH 1000:25:2→1000:100:2) to afford the title compound as a pale brown foam (11.16 g, 44% yield).

Provenance & Evidence