6-amino-3,4-dihydro-2H-1,4-benzoxazin-3-one → 6-[(S)-3-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-propylamino]-4H-benzo[1,4]oxazin-3-one

Participants

Reaction Steps

Starting from 6-amino-4H-benzo[1,4]oxazin-3-one and tert-butyl-dimethyl-((S)-1-oxiranylmethoxy)-silane and using a procedure analogous to that of Example 201, step 201.ii, the title compound was obtained as a pale brown foam (5.2 g, 66% yield).

Provenance & Evidence