反应详情

100 mg (660 μmol) of 4-chloro-1H-pyrrolo[2,3-b]pyridine (from example XVIII), 166 mg (1.31 mmol) of 2-fluoro-4-hydroxyaniline and 73.5 mg (1.31 mmol) of powdered potassium hydroxide are heated at 260° C. for 8 hours. For work-up, the mixture is cooled to room temperature, diluted with water and extracted three times with ethyl acetate. The organic phase is dried over magnesium sulfate and concentrated using a rotary evaporator. The residue is purified by preparative HPLC.

1. extractionextracted three times with ethyl acetate
2. dry with materialThe organic phase is dried over magnesium sulfate
3. concentrationconcentrated
4. customa rotary evaporator
5. customThe residue is purified by preparative HPLC