HCID 58102395, compound → HCID 49800385, compound

HRID 1640868Notes

Reaction equation

HRID 1640868 reaction equation
[OH:1][C:2]([CH3:36])([CH3:35])[CH2:3][C@@:4]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[O:9][C:8](=[O:10])[N:7]([C@H:11]([C:13]2[CH:18]=[CH:17][C:16](B3OC(C)(C)C(C)(C)O3)=[C:15]([CH3:28])[CH:14]=2)[CH3:12])[CH2:6][CH2:5]1.Br[C:38]1[CH:43]=[CH:42][N:41]([CH:44]2[CH2:46][CH2:45]2)[C:40](=[O:47])[CH:39]=1>>[CH:44]1([N:41]2[CH:42]=[CH:43][C:38]([C:16]3[CH:17]=[CH:18][C:13]([C@@H:11]([N:7]4[CH2:6][CH2:5][C@:4]([CH2:3][C:2]([OH:1])([CH3:36])[CH3:35])([C:29]5[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=5)[O:9][C:8]4=[O:10])[CH3:12])=[CH:14][C:15]=3[CH3:28])=[CH:39][C:40]2=[O:47])[CH2:46][CH2:45]1

Participants

3

Reactant 2

HCID 58102395HCID 58102395, compoundHCID 596356474-Bromo-1-cyclopropylpyridin-2(1H)-one

Product 1

HCID 49800385HCID 49800385, compound

Procedure

The title compound was prepared from (S)-6-(2-hydroxy-2-methyl-propyl)-3-{(S)-1-[3-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-ethyl}-6-phenyl-[1,3]oxazinan-2-one and 4-bromo-1-cyclopropyl-1H-pyridin-2-one following a procedure analogous to that described in Step 5 of Example 96. LC-MS (Method 5): tR=3.42 min; Mass spectrum (ESI+): m/z=501 [M+H]+.

Sources & evidence

ORD record
ord-498a8f98163149da90ead61946ff2c7d
Source dataset
uspto-grants-2012_02
Patent number
US08114868B2

Reaction notes

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