HCID 58102371, compound → HCID 66601032, compound

HRID 1640870Notes

Reaction equation

C[C:2]1[CH:26]=[C:25](B2OC(C)(C)C(C)(C)O2)[CH:24]=[C:23](C)[C:3]=1[CH2:4][N:5]1[CH2:10][CH2:9][C:8]([CH2:17][C:18]([OH:21])([CH3:20])[CH3:19])([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[O:7][C:6]1=[O:22].Br[C:38]1[CH:43]=[CH:42][N:41]([CH:44]2[CH2:46][CH2:45]2)[C:40](=[O:47])[CH:39]=1>>[CH:44]1([N:41]2[CH:42]=[CH:43][C:38]([C:25]3[CH:24]=[CH:23][C:3]([CH2:4][N:5]4[CH2:10][CH2:9][C:8]([CH2:17][C:18]([OH:21])([CH3:19])[CH3:20])([C:11]5[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=5)[O:7][C:6]4=[O:22])=[CH:2][CH:26]=3)=[CH:39][C:40]2=[O:47])[CH2:46][CH2:45]1

Participants

Reactant 2

HCID 58102371HCID 58102371, compound

HCID 596356474-Bromo-1-cyclopropylpyridin-2(1H)-one

Product 1

HCID 66601032HCID 66601032, compound

Procedure

The title compound was prepared from 3-[2,6-dimethyl-4-(4,4,5,5-tetramethyl -[1,3,2]dioxaborolan-2-yl)-benzyl]-6-(2-hydroxy-2-methyl-propyl)-6-phenyl -[1,3]oxazinan-2-one and 4-bromo-1-cyclopropyl-1H-pyridin-2-one following a procedure analogous to that described in Step 5 of Example 96. LC-MS (Method 5): tR=3.53 min; Mass spectrum (ESI+): m/z=501 [M+H]+.

Sources & evidence

ORD record: ord-b8d00706cb274fde8535fb864b4b0940
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08114868B2

Reaction notes

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