Hydrazine → HCID 66738290, compound

Participants

Reaction Steps

Add hydrazine (70 mg, 2.12 mmol) to a solution of 2-[2-(6-fluoro-4-iodo-pyridin-3-yloxy)-ethyl]-isoindole-1,3-dione (440 mg, 1.06 mmol) in ethanol (10 mL). Stir the solution at RT overnight. Filter to remove the solid and concentrate the filtrate to a light yellow solid. Purify by column chromatography (10% 2 M ammonia in methanol in methylene chloride) to afford the title compound as a light yellow oil (250 mg, 83.8%). 1H NMR (400 MHz, CD3CN) δ 2.12 (s, 2H), 3.03 (t, J=5.2 Hz, 2H), 4.10 (t, J=5.2 Hz, 2H), 7.47 (d, J=4.0 Hz, 1H), 7.69 (d, J=2.0 Hz, 1H).

Provenance & Evidence