HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 6-Fluoro-4-iodopyridin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (6-Fluoro-4-iodo-pyridin-3-yl)-carbamic acid tert-butyl ester | HCID 66738095 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 6-Fluoro-4-iodopyridin-3-amine | HCID 58266641 | — |
Reaction Steps
Dissolve tert-butyl 6-fluoro-4-iodopyridin-3-ylcarbamate (1.47 g, 4.35 mmol) in DCM (20 mL). Add trifluoroacetic acid (TFA) (20 mL). Stir at RT under N2 for 2 h. Remove the solvent under reduced pressure. Dry in vacuo to afford 6-fluoro-4-iodopyridin-3-amine in TFA salt (1.02 g, 99%) with 100% HPLC purity. MS (ES) m/z 239 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08114872B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-7d6d42959755413888c1db4b09f02e88 |
| Source note | uspto-grants-2012_02 |