Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → HCID 25120910, compound

Participants

Reaction Conditions

Reaction Steps

Add pyridinium p-toluenesulfonate (8.23 mg, 0.03 mmol) to a solution of [5-fluoro-4-(7-{2-fluoro-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-pyridin-4-yl}-benzo[b]thiophen-2-yl)-pyrimidin-2-yl]-(2-[1,2,3]triazol-1-yl-ethyl)-amine (190 mg, 0.32 mmol) in ethanol (4 mL). Stir the mixture at 55° C. overnight. Cool the solution. Concentrate the solution in vacuo to a yellow oil. Purify by column chromatography (methylene chloride to 10% methanol in methylene chloride) to afford the title compound (0.14 g, 88%) as a light yellow solid. MS (ES) m/z 496 [M+1]+.

Provenance & Evidence