Cyclohexene → HCID 66735970, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-[5-(3,5-difluoro-benzenesulfonyl)-1-trityl-1H-indazol-3-yl]-4-[(2-dimethylamino-ethyl)-methyl-amino]-2-nitro-benzamide (1.0 g, 1.25 mmol), cyclohexene (2 mL), 1,4-dioxane (50 mL) and 10% Pd/C (0.1 g) was stirred at 85° C. for 5 hours. More cyclohexene (3 mL) and 10% Pd/C (0.2 g) were then added and the mixture stirred at 90° C. for additional 6 hours. The reaction mixture was then cooled to room temperature and filtered over celite washing thoroughly with ethanol. The filtrate was evaporated to dryness affording the title compound as a pale brown solid (910 mg, 94% yield).

Provenance & Evidence