Triethylamine → N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide

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Reaction Steps

A mixture of N-[5-(3,5-difluoro-benzenesulfonyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-[(tetrahydro-pyran-4-yl)-(2,2,2-trifluoro-acetyl)-amino]-benzamide (1.41 g, 2.0 mmol), triethylamine (5.6 mL) and methanol (30 mL) was stirred at room temperature overnight. The solvents were removed under reduced pressure and the residue treated with methanol (10 mL), stirred at 45° C. for 30 minutes, filtered and dried in oven affording 1.0 g of the title compound as a white solid (81% yield).

Provenance & Evidence