1-Hydroxybenzotriazole → HCID 66736072, compound

Participants

Reaction Steps

The crude N-[5-(3,5-difluoro-benzenesulfonyl)-1-trityl-1H-indazol-3-yl]-terephthalamic acid (0.56 mmol) was treated with dichloromethane (8 mL), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (140 mg, 1.3 eq), 1-hydroxybenzotriazole (98 mg, 1.3 eq) and 4-pyrrolidin-1-yl-piperidine (113 mg, 1.3 eq). The reaction mixture was stirred at room temperature overnight, diluted with dichloromethane, washed with brine and with a saturated solution of sodium hydrogenocarbonate, dried over sodium sulfate and evaporated to dryness affording the crude title compound that was used as such for the next step without further purification.

Provenance & Evidence